| 1. | David Guetta - | United at Home - Dubai Edition | 69,599,785 | = | 1. | 2021-02-06 |
| 2. | Daft Punk - Around The World (Official Video) | 64,042,832 | = | 2. | 2021-10-01 |
| 3. | David Guetta - ft Sia - Titanium (David Guetta & MORTEN Future Rave Remix) [Live Edit] | 62,956,270 | = | 3. | 2021-08-25 |
| 4. | David Guetta - RITA ORA, DAVID GUETTA, IMANBEK – BIG FT. GUNNA [OFFICIAL VIDEO] | 32,541,165 | = | 4. | 2021-02-12 |
| 5. | Daft Punk - Epilogue | 30,010,121 | = | 5. | 2021-02-22 |
| 6. | David Guetta - Shouse - Love Tonight (David Guetta Remix) | 21,724,142 | = | 6. | 2021-06-12 |
| 7. | David Guetta - | United at Home - Paris Edition from the Louvre | 19,014,872 | = | 7. | 2021-01-01 |
| 8. | David Guetta - NYE Livestream from Louvre Abu Dhabi | 16,170,846 | = | 8. | 2021-12-31 |
| 9. | David Guetta - x MistaJam x John Newman - If You Really Love Me (How Will I Know) [Official Video] | 11,011,846 | = | 9. | 2021-07-15 |
| 10. | David Guetta - x MistaJam x John Newman - If You Really Love Me (How Will I Know) [Official Video] | 9,181,863 | = | 10. | 2021-07-01 |
| 11. | David Guetta - – Family (feat. Bebe Rexha, Ty Dolla $ign & A Boogie Wit da Hoodie) [Official Video] | 9,124,572 | = | 11. | 2021-11-23 |
| 12. | David Guetta - live @ Fun Radio Live Stream Experience | 7,995,027 | = | 12. | 2021-01-20 |
| 13. | David Guetta - Memories (ft. Kid Cudi)(2021 remix) [visualizer] | 6,042,713 | = | 13. | 2021-01-08 |
| 14. | David Guetta - Becky Hill, David Guetta - Remember (Official Lyric Video) | 5,475,331 | = | 14. | 2021-06-18 |
| 15. | David Guetta - ft Kid Cudi - Memories (2021 Remix) [Live@United At Home Dubai] | 5,467,016 | = | 15. | 2021-03-18 |
| 16. | David Guetta - live @ Creamfields 2021 | 3,437,200 | = | 16. | 2021-10-05 |
| 17. | David Guetta - & MORTEN – Impossible (ft. John Martin) [Official Music Video] | 3,033,206 | = | 17. | 2021-06-13 |
| 18. | David Guetta - Bad Bunny & Jhay Cortez - Dákiti (David Guetta remix) [visualizer] | 2,715,211 | | | 2021-03-01 |
| 19. | David Guetta - ft Sia - Titanium (David Guetta & MORTEN Future Rave Remix) [Lyric video] | 2,675,117 | v | 18. | 2021-08-20 |
| 20. | David Guetta - – Family (feat. Bebe Rexha, Ty Dolla $ign & A Boogie Wit da Hoodie) [Official Audio] | 1,556,153 | v | 19. | 2021-10-28 |
| 21. | David Guetta - Get Together | 1,377,189 | v | 20. | 2021-05-07 |
| 22. | David Guetta - David Guetta, MORTEN, Roland Clark - Alive Again (Music Video) | 1,330,653 | v | 21. | 2021-12-17 |
| 23. | David Guetta - | Danny Tenaglia 60th Birthday Live | 1,133,626 | v | 22. | 2021-03-08 |
| 24. | David Guetta - Galantis, David Guetta & Little Mix - Heartbreak Anthem (Official Lyrics Video) | 1,097,196 | v | 23. | 2021-05-24 |
| 25. | David Guetta - Joel Corry x RAYE x David Guetta - BED [visualizer] | 912,959 | v | 24. | 2021-02-26 |
| 26. | David Guetta - Joel Corry x RAYE - David Guetta - BED - [David Guetta Festival Mix] | 788,871 | v | 25. | 2021-04-23 |
| 27. | David Guetta - #Shorts Say Hello to David baGuetta ???????????? | 543,810 | v | 26. | 2021-04-25 |
| 28. | David Guetta - – Family (feat. Artik & Asti & A Boogie Wit da Hoodie) [Official Audio] | 498,021 | v | 27. | 2021-11-11 |
| 29. | David Guetta - | United at Home - Dubai Edition (Trailer) | 440,698 | v | 28. | 2021-02-03 |
| 30. | David Guetta - & Sia - Let's Love (Aazar remix) | 432,944 | | | 2021-02-17 |
| 31. | David Guetta - – Family (feat. Bebe Rexha, Ty Dolla $ign & A Boogie Wit da Hoodie) [Lyric Video] | 415,903 | v | 29. | 2021-11-05 |
| 32. | David Guetta - – Family ft Bebe Rexha, Ty Dolla $ign & A Boogie Wit da Hoodie [Guetta Down Tempo Rmx] | 372,203 | | | 2021-12-24 |
| 33. | David Guetta - x MistaJam x John Newman - If You Really Love Me [MistaJam remix] | 362,296 | | | 2021-09-17 |
| 34. | David Guetta - | United at Home - Dubai Edition (Teaser) | 319,782 | v | 30. | 2021-01-26 |
| 35. | David Guetta - x MistaJam x John Newman - If You Really Love Me [Future Rave Remix] | 293,773 | v | 31. | 2021-08-06 |
| 36. | David Guetta - Jason Derulo - Lifestyle (feat. Adam Levine) [David Guetta Slap House Mix] | 285,488 | | | 2021-02-25 |
| 37. | David Guetta - x MistaJam x John Newman - If You Really Love Me [Marten Hørger Remix] | 266,447 | | | 2021-08-13 |
| 38. | David Guetta - Coldplay X BTS - My Universe (David Guetta Extended Remix) [Official Audio] | 253,141 | v | 32. | 2021-11-19 |
| 39. | David Guetta - – Family (ft. Bebe Rexha, Ty Dolla $ign & A Boogie Wit da Hoodie) [Hook N Sling Remix] | 248,490 | | | 2021-11-26 |
| 40. | David Guetta - – Family (feat. Sofia Reyes & A Boogie Wit da Hoodie) [Official Audio] | 90,852 | | | 2021-11-11 |
| 41. | David Guetta - #Shorts Echostage was ??? | 90,206 | | | 2021-06-20 |
| 42. | David Guetta - – Family (ft. Bebe Rexha, Ty Dolla $ign & A Boogie Wit da Hoodie) [Crvvcks Remix] | 84,948 | | | 2021-11-26 |
| 43. | David Guetta - – Family (feat. Lune, Ty Dolla $ign & A Boogie Wit da Hoodie) [Official Audio] | 67,098 | | | 2021-11-11 |
| 44. | David Guetta - Use this sound in your shorts to show the world how much you are proud of your friends and family ✨ | 56,700 | | | 2021-11-19 |
| 45. | David Guetta - – Family (feat. Jamie, Ty Dolla $ign & A Boogie Wit da Hoodie) [Official Audio] | 50,686 | | | 2021-11-11 |
| 46. | David Guetta - – Family (feat. Imen Siar, Ty Dolla $ign & A Boogie Wit da Hoodie) [Official Audio] | 33,434 | | | 2021-11-11 |
| 47. | David Guetta - – Family (feat. Bebe Rexha, Ty Dolla $ign & A Boogie Wit da Hoodie) [22Bullets Remix] | 28,356 | | | 2021-11-11 |
| 48. | David Guetta - – Family (feat. Julie Bergan, Ty Dolla $ign & A Boogie Wit da Hoodie) [Official Audio] | 23,120 | | | 2021-11-11 |
| 49. | David Guetta - – Family (feat. IZA, Ty Dolla $ign & A Boogie Wit da Hoodie) [Official Audio] | 21,455 | | | 2021-11-11 |
| 50. | David Guetta - – Family (feat. Annalisa, Ty Dolla $ign & A Boogie Wit da Hoodie) [Official Audio] | 20,527 | | | 2021-11-11 |